Three million people in Europe are estimated to have moderate or greater TR5
Risks of tricuspid regurgitation
If your patients are experiencing fatigue, shortness of breath and a poor quality of life, severe tricuspid regurgitation (TR) is an often overlooked aspect of heart failure (HF) that could be the cause.1–3
TR is prevalent yet frequently overlooked3–5
Significant TR is common in the elderly population as well as in patients with HF, but it remains undertreated.1,4–6
6.6% of adults ≥75 years old were found to have moderate or greater TR in a large, international prospective study in the UK7
Fewer than 1% of patients with moderate or greater TR are treated with surgery annually1
TR is classified according to different aetiologies8
In 90% of cases, TR is due to annular dilatation, defined as secondary TR.8
TR secondary to HF is common and has considerable impact on survival and hospitalisation rates6
Adapted from Heitzinger G, et al. Eur J Heart Fail. 2023;25(6):857–867. Based on data from Vienna, Austria.
TR may often develop secondary to HF, and moderate-to-severe secondary TR is common across all HF subtypes.6
Moderate or greater secondary TR can worsen HF symptoms and diminish patient quality of life. As TR severity increases, so does the risk of mortality, independent of the underlying HF subtype.6
HF: heart failure; HFmrEF: heart failure with mildly reduced ejection fraction; HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with reduced ejection fraction.
Increasing severity of secondary TR with HF is associated with a higher mortality risk compared to no or mild secondary TR.6
HF: heart failure; HR: hazard ratio; TR: tricuspid regurgitation.
TR severity is an indicator of mortality risk in patients with HF with preserved ejection fraction (HFpEF) in the setting of acute HF9
Secondary TR appears to have a more direct prognostic impact on 1-year survival in HF with HFpEF than in HF patients with reduced ejection fraction (HFrEF).9
All-cause mortality in patients admitted for acute HF
Adapted from Santas E, et al. Circ J. 2015;79(7):1526–1533. HF: heart failure; HFpEF: HF with preserved ejection fraction; HFrEF: HF with reduced ejection fraction; TR: tricuspid regurgitation.
HF and TR have similar symptoms. Patients with both may be more symptomatic with worse prognosis10–13
TR and right HF may result in debilitating symptoms and poor outcomes when not adequately treated.1, 13–17 Moderate or greater TR is the most important predictor of residual congestion at discharge after acute hospitalisation for HF.15
The impact of moderate-to-severe TR and the relevance of the right heart in the circulatory system13-17
*Moderate-to-severe TR is one of the key predictors of congestion at discharge in patients with acute HF
.
GI: gastrointestinal; HF: heart failure; LV: left ventricle; TR: tricuspid regurgitation.
TR may present alongside other medical conditions
Patients with moderate or greater TR may have multiple comorbidities, including pulmonary hypertension (PH), atrial fibrillation (AF) and HF.18–21
Pulmonary hypertension
TR severity correlates with PH disease severity. Moderate or severe TR is strongly associated with poor prognosis in patients with PH18
Heart failure
In patients with acute HF, moderate or greater TR is associated with higher mortality risk at 1 year than trivial or mild TR19
Atrial fibrillation
Almost one-third of patients with AF developed moderate or greater TR over time21*
*Based on a population-based study in the USA.
I kept gaining weight and no one could figure it out. Diuretics were not working. I couldn’t breathe. The doctor said we're going to admit you because we believe it's HF. And after I had an echocardiogram, the hospitalist came in and said that I had severe TR.
-Linda, TR patient
Explore TR treatment options
